“The death toll in the unrest after Bhutto's death is 10, mostly in Sindh province,” Interior Ministry spokesman Javed Cheema told news agency AFP.
He said dozens of people had been wounded in the violence, which hit several cities across the country as buildings and cars were torched.
Two people were shot dead in rioting in the eastern city of Lahore and four others were killed in the southern province of Sindh, Bhutto's birthplace and stronghold, police said. Another four were killed in Karachi.
Sporadic gunfire could be heard echoing around the streets of Lahore where shops and vehicles could be seen on fire.
The markets and shops immediately closed down as paramilitary patrols roamed the streets in an attempt to keep a lid on the violence, a local police officer told AFP.
In the southern metropolis of Karachi police said at least 70 vehicles were burnt by protesters, including 35 trucks filled with wheat. All petrol pumps were immediately closed as knots of protesters blocked many roads.
Witnesses said that as news spread of Bhutto's assassination in a suicide attack, the streets of Karachi were clogged with traffic as panicked people tried to rush home.
The mood was tense in Bhutto's home town of Larkana where two banks were set on fire, witnesses said.
In Peshawar in the northwest police used tear gas and batons to break up angry crowds; and in the central city of Multan some protesters fired shots into the air and many shouted slogans including “Musharraf is a dog” and “Long live Bhutto”.
As angry Bhutto supporters looked for a scapegoat for her death, residents in the Sindh town of Jacobabad said shops belonging to the family of interim Prime Minister Mohammedmian Soomro were burned down.
Portraits of Soomro were set on fire while demonstrators took to the streets, blocking roads and a railway track. The main court, banks and other buildings were also set on fire, an AFP reporter said.
Fearing renewed violence in the northwestern valley of Swat, which has been troubled by months of religious militancy, officials clamped a curfew on the picturesque region, a local official told reporters.